And became the chances of Manchester United to qualify for the Champions League subject to accurate calculations and is not controlled by alone, as he remained bottom of the group standings with four points equally with Copenhagen Danish, who later faces Bayern Munich (12 points), knowing that the latter already guaranteed the top of the group and qualified for the knockout rounds.
Galatasaray, on the other hand, are in second place with 5 points, and have kept their chances high ahead of the clash with Copenhagen in the last round.
Man United have one game left against Bayern in the continental competition, and will be required to win at Old Trafford to keep any hopes of qualifying alive.
The goals for the Reds were scored by Argentina's Alejandro Garnacho (11), Portugal's Bruno Fernandes (18) and Scott McTominay (55), while Ziyech scored twice for the Turkish side (29 and 62), and Turkey's Kerem Akturkoglu added the third (71).
Dutch coach Erik ten Hag's team showed their unbridled desire to win early and make up for their consecutive setbacks at the Chamünslig, where they achieved only one win out of 4 games, and fell in the previous round to Copenhagen 4-3.
The "Red Devils" opened the scoring through Garnacho, who entered the meeting with high morale after scoring an acrobatic goal against Everton at the weekend, and opened the scoring in Istanbul after a pass from Fernandes (11).
Fernandes went from passing to top scorer seven minutes later, doubling his team's lead, after hitting a beautiful curved ball from the outskirts of the area (18).
Galatasaray refused to hand over the match and Moroccan international Ziyech managed to keep his fortunes alive, reducing the deficit before half-time with a direct free kick from 23 meters (29).
United thought they had sealed the score when McTominay scored a third goal early in the second half following a counter-attack (55). Once again, Ziyech proved his heel and kept his team in the game with another free-kick (62) after Cameroonian goalkeeper André Onana made a mistake in saving it.
The hosts turned the game upside down and equalized the score again, and Ziyech played a pivotal role after passing to Kerem Akturkoglu, who received it brilliantly and shot it into the top corner (71).