Update knowledge of "COVID-19" Assoc.

(Molnupiravir) cannot be used to prevent COVID-19.

The above points are based on the MOVe-AHEAD study involving 1,500 people from 19 countries around the world.

living with a family member infected with COVID-19

by evaluating the effectiveness of drugs that can help prevent COVID-19

In a group of people who have close contact with an infected person or not?

It was found that the drug group

"Molenupiravir" reduces the risk of developing COVID-19

23.6% less than the placebo group, but not significantly different.

The next issue...death from COVID-19

That is considered a huge economic loss to Silva S and his team from the United States.

published in Scientific Reports (February 22, 2023) evaluating the social and economic impact of the loss of life from COVID-19.

More than a million people

The essence found

losses from COVID-19

That reduced the average lifespan of the population by 3.08 years and estimated economic losses of up to $3.57 trillion.

Another interesting updated knowledge, "Metformin" helps reduce the amount of viruses.

Reduce the risk of getting sick, going to the hospital and dying, including "Long Covid"

The origin of this story comes from the results of the recent COVID-OUT Trial presented at the CROI 2023 Conference, USA by Bramante C of the University of Minnesota, who studied 1,323 patients from six hospitals.

Metformin was found to reduce viral load 4.4 times better than placebo. Metformin's viral clearance effect was comparable to Paxlovid at day 5 and better than Paxlovid at day 10.

In addition, the group receiving the drug had a 58% reduction in the risk of severe illness and death and a 42% reduction in the risk of trying COVID-19.

Assoc. Prof. Dr. Teera said that, however, you still need to follow up on other research from around the world to see if there are studies that have been effective in the same direction or not.

In order to have more confidence and lead to wider application considerations

“...live with consciousness

Protect yourself regularly.

Adjust the living environment, study, eat, drink, work place to be better ventilated.

Wearing a mask correctly can greatly reduce the risk of not getting infected or not getting reinfected is the best, paying attention to the health of yourself and your family.

is important.”

Japan drug update “Ensitrelvir fumarate (S-217622)”

As we have known since the end of last year that

Japan has approved the drug "Xocova" or "Ensitrelvir Fumarate" to treat people infected with COVID-19.

with mild to moderate symptoms

There is research evidence that clearly supports that it can reduce the duration of illness.

and is safe

With side effects, for example, it may cause a decrease in HDL fat levels and increase triglyceride levels.

The dose used was 125 mg once a day for 5 consecutive days (375 mg on the first day).

Recently, the CROI 2023 global infectious disease conference is taking place in Seattle, USA, with important information that is exciting and closely watching the world.

The results of clinical trials were presented in a randomized and comparative group.

A more in-depth study of 1,821 people in Japan, South Korea and Vietnam.

It was found that administration of this drug at a dose of 375 mg on the first day (three 125 mg tablets) followed by 125 mg for another 4 days within 120 hours (5 days) after the onset of illness

96% of those receiving the drug were undetectable at day 4 (after 3 doses).

In addition, it is important

Patients were followed up at 3 months and 6 months to assess the rate of "Long COVID" problems (14 symptoms were defined in this study). The administration of this drug reduced the risk by 45. % compared to the non-drug group (14.5% in the drug group and 26.3% in the non-drug group).

...statistically significant difference

if so

It is good news that the world will have weapons in the fight against COVID-19.

both for

"Treat COVID-19" and help reduce the risk of "Long COVID" as well.

However, the US NIH also recently announced a research program on the drug.

will be studied in a group of patients with COVID-19

hospitalized

It was announced in mid-February.

It is another important matter to continue to follow and update news.

for guidelines for updating virus strains to produce

“Vaccines”... The World Health Organization team published this article in the medical journal Nature Medicine (February 20, 2023). The information needed for vaccine planning comes from many sources.

Since the cooperation of countries

in monitoring the spread of the COVID-19 virus

It provides complete, regular and timely reporting, including laboratory analyzes, on how changes in viral strains affect infectious performance, transmission, immune resistance.

And...or affect the cause of the pathology...how much more severe is the illness?

The important thing is...

Assessing whether existing vaccines are still effective against the strains of the virus found.

The above information will lead to the planning process for research and development of new vaccine products.

to be used for testing concurrently and thus leading to production management planning

to lead to wider use

with current status

The main academic information available and used.

Most of them are from mRNA-type vaccines, while other platform vaccines are less well known.

At present, although ... in Thailand, we have the number of patients treated in the top hundreds of hospitals, there are less than 10 single-digit deaths ... with the estimate of the number of new infections just around the digits. early thousand only

Still, everyone should live a conscious life, not be careless, and protect yourself regularly.

"Wearing a mask properly

It will greatly reduce the risk of both COVID-19 and PM2.5, ”Assoc. Prof. Dr. Thira said.

“Caring about the health of yourself and your family members.

It will help support us to have welfare and safety in an era where the epidemic still exists.

And it's not over yet.”

Emphasize that ... each infection can cause illness, death, and the risk of long-term abnormalities such as "Long Covid" as well ... protecting oneself from infection

or not repeating is the best

However, “COVID-19” is still more dangerous.

"Influenza" for patients infected with COVID who are hospitalized

The risk of death is 1.5 times higher than influenza...This study reinforces the importance of regular self-prevention.

Especially people who are elderly or have chronic diseases.