Sharpless (left) won the Nobel Prize in Chemistry for the first time in 2001, the first time in 21 years.

The picture shows the award in 2001.

(AFP file photo)

[Compiled by Guan Shuping/Comprehensive Report] Three scholars from the United States and Denmark have developed "click chemistry" and "bioorthogonal chemistry" to "buckle" molecules together in a simple and effective way. Laying the foundation for more functional forms of chemistry, he won this year's Nobel Prize in Chemistry on the fifth day.

Sharpless wins chemistry crown for second time in 21 years

The three scholars are Carolyn R. Bertozzi, a professor of chemistry at Stanford University, K. Barry Sharpless, a professor of chemistry at Scripps Research Center, and Morten Meldal, a professor of chemistry at the University of Copenhagen, Denmark. .

This is the 81-year-old Sharpless who won the Chemistry Prize again after 2001. He is also the fifth person in history to win the Nobel Prize twice; Bertozzi is the Nobel Prize winner over the years. Eighth female recipient of the Bell Prize in Chemistry.

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3 people have successively studied to open the application of living organisms

The jury of the Chemistry Prize noted that "click chemistry" snapped molecular building blocks together as quickly and efficiently as snaps, while avoiding unwanted by-products. Sharpless was the first to propose "click chemistry" around 2000 "The concept of ", soon after, he and Meldahl published "copper catalyzed alkyne-azide cycloaddition reaction" (CuAAC), which uses copper ion catalysis to "buckle" molecular building blocks together, which is simple and effective. It's like opening the floodgates," making this response widely used by scientists.

"This is an elegant and efficient chemical reaction that is now widely used," the jury said, including the development of drugs, from mapping DNA to making new materials that are more fit for purpose.

Sharpless and Meldal laid the groundwork for "click chemistry," while Bertozzi took click chemistry to new frontiers, opening up applications in living organisms.

For improving the accuracy of cancer diagnosis and treatment

To map glycan molecules on the cell surface, Bertozzi developed "bioorthogonal chemistry," a type of click chemistry that works in living organisms without interfering with the normal chemistry of cells.

Reviewer Ramstrom said Bertozzi's research "revolutionizes the way we analyze or see molecules in living organisms" and is now being used to improve the accuracy of cancer diagnosis and treatment, DNA sequencing and more.

The jury noted, "Click chemistry and bioorthogonal chemistry, bringing chemistry into the age of functionalism, are bringing the greatest benefit to mankind."

Meldal said in an interview with Swedish Public Radio that it was "very unexpected and very honoured" to receive the Nobel Prize in Chemistry.

After learning of the award, Bertozzi said in a phone interview that she was "extremely shocked" and "could hardly breathe". She was not quite sure that this was true for a while. She said that click chemistry is still in a very early stage, and in biotechnology, In terms of disease treatment and other aspects, there are still many new reactions and applications to be discovered and created, especially in medicine and "drug delivery", "These will be areas where click chemistry will have a very powerful impact, and it has already made an impact."