Itchy, allergic skin rash

stubborn doctor

14 Aug 2022 05:20





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as a matter of fact

The doctor was not a dermatologist, but a pharmacologist, internist, and brain doctor, who was trained in brain immunology.

and especially brain infections

and came across this article

that are linked to the brain and variability

When is someone itchy?

Having chronic scratching, rash (atopic dermatitis), the advice that we will look at is a formula that we all make.

for example

Keep an eye out for what happened and what happened.

including dust mites, dust, pollen

pet doctor

Don't use soaps, especially those containing bacteria-killing drugs, as they can dry out your skin very much if irritation develops.

watch for symptoms

And if the symptoms are not much, it is recommended to buy steroids, topical steroids, antihistamines, which are common.

but if severe

It is advisable to see a dermatologist or a skin allergy specialist.

That comes with a headache with itchy rash

It's in this era of covid.

After the infection has cleared, it resumes, followed by a blistering rash.

Is it locally or throughout the body?

and the important thing is

The rash is mixed with itching. This is not counted with other symptoms such as hair loss, joint pain, sleep problems that are like sleeping for eight to nine hours.

But during the day, still tired, need to rest, and when the quality of sleep is captured

It turned out that there was almost no deep sleep that a normal person needed about 75 minutes.

Coming back to itching and skin rashes.

It's a variance in the immune system.

and if the symptoms are severe and severe to the point of requiring special medication

It is an IgG4 monoclonal antibody that is specific to IL-4R alpha, a receptor of IL-13 and delays the action of IL-13 and IL-4 and goes beyond the generation of IgE. 10,000 baht per needle

And the drug that is used often enough is montelu kast, which is used in patients with asthma and bronchial stenosis, but when used in itchy rash.

Returned with limited or no effect at all.

Important work explaining the mechanism of occurrence of the itch.

whether it occurs short-term or chronically

It is reported in the 2021 journal Proceeding National Academy of Science (PNAS) by teams from Brigham and Women's Hospital and Harvard Medical School and Massachusetts General Hospital.

By Chui et al. found that the cause of Kankaye origin

It is located in the sensory ganglia that we call the dorsal root ganglia (DRG).

Indeed, it is useful in protecting oneself from something benign.

But when it becomes chronic

will become a torture for that person's life

Leukotrienes (LTs) are eicosanoid lipid mediators secreted upon activation of immune system cells, white blood cells, mast cells, eosinophils, basophils and macrophages, and other cells including leukotrienes.

platelet–neutrophil aggregates and tuft cells. LTs consist of LTB4 and cysteinyl LTs (CysLTs; LTC4 LTD4 LTE4).

results of the study

It is a proof of communication link.

or as we like to call it

LTC4 is delivered to the ganglia that contain large amounts of CysLT2R receptors and induces itching.

The other receptors were not associated with either cysltr1 and Trpv1.

Can't explain this chronic itch.

It also explains why montelukast is not so good at relieving and treating itching.

Because the different targets were captured at CysLT1R, not CysLT2R, although this study was done in rats.

but can completely dissect the mechanism

There is a high probability of using drugs that are specific to inhibiting the conversion of arachidonic acid, which is the precursor to LTR4, such as 5-LO inhibitor zileuton.

Subsequent reports in the 2022 Frontiers in Neural Circuits coordinated the rod mechanism.

which will send such feelings to the brain

and require scratching through the system in the spinal cord

All specific regions of the brain fall into the Spino-Parabrachial pathway, and mechanical itch stimulus has also been reported via the PIEZO1 mechano-sensor receptor.

Reported in the journal Nature 2022.

It can be seen that itching, scratching, picking, and sheep all have complex mechanisms.

And even though it seems a little bit for the general public

but actually

It's a big deal for people who are

and reflects a volatile immune system.

It affects the receiver and determines the itching sensation.

through to the brain and lead to scratching

(But will it be the more itchy, the more you scratch, the more you scratch, the more it gets?) And I hope that in the future there will be a drug that is not cruel for anyone who has this disease.

stubborn doctor