Spain reported its second monkeypox-related death on Saturday, in what is believed to be Europe's second death toll from the disease and only the third outside Africa in the current outbreak.

Spain reported its first death on Friday, shortly after Brazil reported its first monkeypox-related death outside the African continent in the current wave of the disease, the Telegraph reported.

According to a World Health Organization report from July 22, only five deaths had been reported, all in the African region.

The WHO last Saturday declared the rapidly spreading outbreak a global health emergency, the highest level of alert.

In its latest report on Saturday, the Spanish health ministry said 4,298 cases had been confirmed in the country.

Of the 3,750 patients for whom information was available, 120, or 3.2 percent, had been hospitalized and two had died, the report said without giving further details.

The first death occurred in the northeastern region of Valencia and was caused by encephalitis, an infection-related inflammation of the brain, local media reported.