The woman took a large amount of sleeping pills and acetaminophen for pain relief and was sent to the hospital for emergency treatment.

schematic diagram.

(Composite photo, photo by reporter Yan Hongjun, provided by Changhua Hospital)

[Reporter Yan Hongjun/Changhua Report] A 45-year-old woman surnamed Chen in Changhua County swallowed 120 sleeping pills and was sent to the hospital by her family. Swallowed sleeping pills to fall asleep, and then swallowed more than 20 acetaminophen pills due to headaches, resulting in explosive hepatitis. The doctor detoxified for the second time and saved Chen's life.

In this case, Ms. Chen had the habit of taking sleeping pills. On the day she was sent to the hospital, her family members found that she was walking unsteadily at home, and she was injured all over her body. She was sent to the emergency department of the hospital in a daze. Then, she took hundreds of sleeping pills in one day. After detoxification, she slowly regained consciousness, but she still had abnormal headache and nausea. Her family transferred her to the emergency department of Changhua Hospital.

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Liao Yaopan, Director of the Toxicology Department of Changhua Hospital, said that after arriving at the hospital, Ms. Chen continued to suffer from nausea and discomfort. She was hospitalized for observation, and she developed explosive hepatitis in a blood test the next day. The liver inflammation index ALT and AST rose to 5000 (normally below 40). He was in danger of liver failure and was rushed to the intensive care unit.

Liao Yaopan said that if Ms. Chen had overdosed on sleeping pills, she should get better after detoxification, but she developed severe explosive hepatitis. It was judged to be drug poisoning, and Ms. Chen, who was physically and mentally unstable, said that she seemed to have taken a lot of acetaminophen. After the antidote, the condition gradually improved, the hepatitis index dropped, and he was discharged after 5 days, and the hepatitis index dropped to 40 after a week.

Liao Yaopan said that acetaminophen is an antipyretic and pain-relief medicine, and the intermediate products produced by its metabolic mechanism are metabolized by the liver. However, when the excess is overdose, the liver cannot bear the burden and cannot metabolize the toxic intermediate products, which will cause liver damage and may cause acute hepatitis. , and even life-threatening liver failure.

The U.S. Food and Drug Administration (FDA) pointed out that about 1,600 people in the United States suffer from liver failure due to overdose every year. According to the statistics of the American Medical Association, more than 1,500 people died of this in the United States in the 10 years from 2000 to 2010, which shows its seriousness.

Liao Yaopan appealed that acetaminophen is a mild and effective drug, which can be bought in general pharmacies and is easy to obtain, but it must not be excessive. Adults can only take 4 to 6 acetaminophen tablets (500 mg each) a day, and acetaminophen taken for a short time exceeds 7.5 grams (about 15 tablets), or a child who takes more than 140 mg per kilogram of body weight, there is a risk of poisoning.

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keywords

  • sleeping pills

  • drug poisoning

  • Headache

  • Liver failure

  • Antidote

  • Violent hepatitis

  • Physically and mentally unstable

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