Chen Yucong reminded that a very small number of people will develop "Steven Johnson syndrome" and "toxic epidermal necrolysis" after taking gout drugs, and symptoms such as painful erythema, rash and skin erosion will appear all over the body.

(picture taken from freepik)

[Health Channel/Comprehensive Report] A 45-year-old woman came to the clinic for help due to rashes, blisters, and ulcerated lips all over her body. After checking her medical records and medication information, the doctor found that she was suffering from gout and was taking uric acid-lowering drugs. Surprised that it might be a rare allergic reaction of "Steven Johnson Syndrome", she was immediately referred to a large hospital. Thanks to early detection, her symptoms were relieved and her condition was stable.

Most patients with gout will take Allopurinol, a long-established drug whose ingredient is isopurinol.

In this regard, Chen Yucong, the deputy director of Yafeng Skin Beauty Clinic, posted a post on the Facebook fan page "Chen Yucong Dermatologist", pointing out that after taking this drug, a very small number of people may develop "Stevens-Johnson Syndrome" (SJS) or Toxic Epidermal Necrolysis (TEN)

Please read on...

Symptoms of SJS and TEN include painful erythema, rash, and skin erosion all over the body. In severe cases, it may lead to large-scale separation of the dermis and epidermis, skin necrosis, and mucosal ulceration. The mortality rate is quite high.

SJS and TEN have low morbidity but high mortality

Chen Yucong said that the main symptoms of SJS and TEN are painful erythema, rash, blisters and skin erosion all over the body. Mucous membranes are also affected.

Although the incidence rate is low, severe cases can lead to large-scale separation of dermis and epidermis, skin necrosis, and mucous membrane ulceration. It may require admission to the intensive care unit for burns and scalds. If not treated in time, the mortality rate is quite high.

Initially symptomatic treatment with systemic corticosteroids

Chen Yucong pointed out that at the early stage of symptoms, systemic corticosteroid therapy should be used as the first-line treatment as soon as possible. In the acute stage, immunosuppressive therapy must be considered to control inflammation and reduce the risk of infection.

Severe cases may develop sepsis and require antibiotic treatment.

In addition, patients after recovery sometimes have sequelae, especially eye vision loss, dry eye, conjunctivitis, and corneal erosion, and the most serious may be blindness.

In addition, the Taiwanese research team found that people with a specific gene HLA-B*5801 have a higher risk of suffering from SJS after using Anleprinol; After taking film-coated tablets (Carbamazepine), it was associated with the risk of developing SJS.

Enleprinol tablet is effective in treating gout, gouty arthritis and uric acid stones, so it is still the most commonly prescribed drug by doctors.

In this regard, Chen Yucong reminded that if patients have symptoms such as fever, sore throat, broken mouth or skin rash after taking the medicine, they must seek medical attention immediately.

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