The doctor reminded that XBB.1.5 has stronger immune escape ability and stronger transmission ability, so we need to pay close attention to it; the picture shows the situation.

(picture taken from freepik)


[Health Channel/Comprehensive Report] According to the latest detection data of the new coronavirus strains updated by the US CDC on December 30, 2022, the XBB.1.5 mutant strain has accounted for 40.5% of the newly detected strains in the United States, which is twice that of a week ago. 4 times that of 2 weeks ago, XBB.1.5 has accounted for 75% of the newly detected strains. In this regard, Wu Changteng, the attending physician of the Pediatric Emergency Department of Linkou Changgung Hospital, reminded that XBB.1.5’s immune escape ability has become stronger and its transmission power has also increased. We need to pay close attention.

Wu Changteng posted on the Facebook page "543-Doctor Wu Changteng for Pediatric Emergency" to share that although several studies have shown that the pathogenicity of XBB.1.5 has not increased, the symptoms include headache, sore throat, nasal congestion, general pain, and fatigue , fever, etc., its symptoms are not much different from other Omicron strains that are currently prevalent, but XBB.1.5 is more likely to combine with human cells.

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Wu Changteng explained that XBB was produced by the recombination of BA.2 lineage BJ.1 and BM.1.1.1 in the summer of 2022.

XBB is the strain with the strongest evasion ability to the antibodies tested, far exceeding BA.5 and approaching the degree of escape of SARS-CoV-1.

According to research analysis, 10 out of 14 BA.2 breakthrough infection sera and 9 out of 20 BA.5 breakthrough infection sera failed to neutralize XBB.

Wu Changteng further pointed out that although XBB.1.5 has no stronger immune escape than XBB, it has a higher intrinsic infectivity because it has an additional key mutation F486P, which binds more tightly to the ACE2 receptor.

That is, XBB.1.5 is more likely to infect and invade human cells.

Therefore, the immune barrier formed by previous vaccination and group infection may not be effective against XBB.1.5, thereby increasing the risk of secondary infection.

Wu Changteng said that although there is early evidence that XBB has a higher risk of secondary infection compared with other Omicron variants.

But current research shows that most secondary infections will be milder than the first.

However, for vulnerable groups with low immunity, such as the elderly with underlying diseases, they may face high risks after secondary infection. Studies have shown that the prognosis of secondary infection in high-risk groups is not good.

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keywords

  • Wuhan pneumonia

  • COVID-19

  • secondary infection

  • novel coronavirus disease

  • XBB

  • XBB.1.5

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