The doctor suggested that instead of relying on intestinal bacteria transplantation to lose weight, it is better to choose diet control and other methods with more scientific evidence; the picture shows the situation.

(The picture is taken from photoAC)

[Health Channel/Comprehensive Report] There are hundreds of ways to lose weight. Do you think transplanting gut bacteria from thin people can help lose weight?

Cai Mingjie, a specialist in endocrinology and metabolism, pointed out that a new study shows that there is no significant relationship between weight loss and intestinal bacteria itself. Because human intestinal bacteria are more complex than mice, the results of fecal intestinal bacteria transplantation that can reduce weight in mouse experiments in the past , does not apply.

Cai Mingjie shared in the Facebook fan page "Dr. Cai Mingjie Health. Weight Loss", and the "Journal of the American Medical Association" (JAMA) published a new study in which 41 obese subjects were recruited in a double-blind randomized controlled experiment. The quality index (BMI) falls at 42.5, and the average age is 48 years old, both men and women.

Among them, 21 subjects received intestinal bacteria transplantation from lean people's feces (referred to as the bacteria group); the other 20 people received a placebo, that is, transplanted their own intestinal bacteria to themselves (referred to as the placebo group), and the transplantation method Enterobacteria are implanted into the small intestine by endoscopy.

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There was no significant difference between the experimental group and the control group

Cai Mingjie explained that all subjects will first undergo a very low-calorie diet for about 4 weeks as a preparation for weight loss before surgery.

Six months after gut microbiota transplantation, 34 subjects underwent gastric bypass bariatric surgery and 4 subjects underwent sleeve gastrectomy.

He pointed out that the results of the study showed that 6 months after the "intestinal bacteria transplantation", the bacteria group lost 4.8% of body weight; the control group lost 4.6% of body weight, and there was no significant difference between the two groups.

Twelve months after the "bariatric surgery", the Bacteria group lost 25.3% of their body weight, while the control group lost 25.2%, but there was no significant difference between the two groups.

Weight Loss Attributable to Diet, Bariatric Surgery

Cai Mingjie explained that there was no significant difference in the weight loss of the two groups of subjects, which means that after receiving fecal transplants, the subjects lost weight may be due to a very low calorie diet (calorie deficit) and subsequent weight loss surgery Later, the successful weight loss was due to surgery, and in both cases it was not due to gut bacteria.

Cai Mingjie said that fecal intestinal bacteria transplantation, which has been used to reduce weight in mice in the past, cannot be directly applied to humans.

Due to the relatively complex intestinal bacteria in the human body, the causal relationship between intestinal bacteria and weight loss has not yet been clearly answered.

It is recommended that instead of relying on intestinal bacteria transplantation, it is better to achieve weight loss through diet control and weight loss surgery, which are more reliable and have more scientific evidence.

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keywords

  • lose weight

  • low calorie

  • bariatric surgery

  • fecal transplant

  • gut bacteria

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